Aeglea

PUBLICATIONS

You can learn more about our research and development through scientific publications and presentations from the Aeglea team and our collaborators.

Select a Program

October 2020

Development of a Novel Human Engineered Enzyme (ACN00177) for the Treatment of Homocystinuria

Christopher Daige, Jason Wiggins, Silvia Ferrati, Leslie Priddy, Jess Van Cleef, Danlee Enzler, James Campbell, Giulia Agnello, and Scott Rowlinson

American Society of Human Genetics Annual Meeting

October 2020

Arginase 1 Deficiency Masquerading as Hereditary Spastic Paraplegia: Implications for Diagnostic Testing

MC McNutt, MW Bechter, AM Trucillo

Joint 16th International Child Neurology Congress and 49th Annual Child Neurology Society Virtual Meeting

May 2020

1 Year Data from First in Human Study of Pegzilarginase for the Treatment of Arginase 1 Deficiency (ARG1-D)

Diaz GA, Bechter MW, Sloan LS, Rao RM, Zori RT

Congress of the European Academy of Neurology

October 2019

Improved Mobility and Adaptive Behavior in Patients with Arginase 1 Deficiency Following Pegzilarginase Treatment

George A Diaz, James E Wooldridge, Mark W Bechter, Gillian Bubb, Roberto T Zori

Annual Metting of the Japanese Society for Inherited Metabolic Diseases (JSIMD)

September 2019

Delays in Diagnosis are Associated With Poor Clinical Outcomes in Patients With Arginase 1 Deficiency

George A Diaz, Nicola Longo, Gillian Bubb, Susan L Potts, Mark W Bechter, James E Wooldridge, J Lawrence Merritt II

European Paediatric Neurology Society (EPNS) Congress

September 2019

Sustained Lowering of High Plasma Arginine Levels in ARG1-D With Pegzilarginase is Accompanied by Improvements in Disease Manifestations

George A Diaz, Andreas Schulze, Markey C McNutt, Elisa Leão Teles, J. Lawrence Merritt II, Gregory M Enns, Spyros P Batzios, Robert L Conway, Mark W Bechter, Susan L Potts, Gillian Bubb, James E Wooldridge, Roberto T Zori

Annual Symposium of the Society for the Study of Inborn Errors of Metabolism (SSIEM)

September 2019

Randomised, double-blind, placebo-controlled phase 3 study to evaluate pegzilarginase in patients with arginase-1 deficiency

George A. Diaz, Mark W. Bechter, Susan L. Potts, Gillian Bubb, James E. Wooldridge, Markey C. McNutt

Annual Symposium of the Society for the Study of Inborn Errors of Metabolism (SSIEM)

April 2019

Sustained Reductions in Plasma Arginine Following Pegzilarginase Administration in Patients with Arginase-1 Deficiency are Accompanied by Improvements in Mobility and Adaptive Behavior

Diaz GA, Schulze A, McNutt MC, Teles EL, Merritt II JL, Enns GM, Batzios SP, Conway RL, Bechter M, Eckert S, Bubb G, Wooldridge JE, Zori RT

Society for Inherited Metabolic Disorders (SIMD) Annual Meeting

November 2018

Clinical Features of Arginase 1 Deficiency: Review of Global Literature

Wooldridge JE, Diaz GA, Longo N, Schulze A, Bubb G, Eckert S, Patki KC, Merritt II JL

Annual Metting of the Japanese Society for Inherited Metabolic Diseases (JSIMD)

October 2018

Improved Survival & Amelioration of Disease-Related Liver Pathology in a Mouse Model of Homocystinuria with a Novel Homocysteine Degrading Enzyme

Christopher Daige, Wayne Lu, Matthew Bonem, Jason Wiggins, Giulia Agnello, James Wooldridge, Everett Stone, George Georgiou and Scott Rowlinson

American Society of Human Genetics Annual Meeting

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