You can learn more about our research and development through scientific publications and presentations from the Aeglea team and our collaborators.

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January 2021

Arginase 1 Deficiency (ARG1-D): A Systematic Literature Review

October 2020

Development of a Novel Human Engineered Enzyme (ACN00177) for the Treatment of Homocystinuria

October 2020

Arginase 1 Deficiency Masquerading as Hereditary Spastic Paraplegia: Implications for Diagnostic Testing

May 2020

1 Year Data from First in Human Study of Pegzilarginase for the Treatment of Arginase 1 Deficiency (ARG1-D)

October 2019

Improved Mobility and Adaptive Behavior in Patients with Arginase 1 Deficiency Following Pegzilarginase Treatment

September 2019

Delays in Diagnosis are Associated With Poor Clinical Outcomes in Patients With Arginase 1 Deficiency

September 2019

Sustained Lowering of High Plasma Arginine Levels in ARG1-D With Pegzilarginase is Accompanied by Improvements in Disease Manifestations

April 2019

Sustained Reductions in Plasma Arginine Following Pegzilarginase Administration in Patients with Arginase-1 Deficiency are Accompanied by Improvements in Mobility and Adaptive Behavior

November 2018

Clinical Features of Arginase 1 Deficiency: Review of Global Literature

October 2018

Improved Survival & Amelioration of Disease-Related Liver Pathology in a Mouse Model of Homocystinuria with a Novel Homocysteine Degrading Enzyme

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